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Cardiovascular Diseases

Cardiovascular homeostasis is highly dependent on endothelial cells that are important constituents of blood vessels. They play critical roles in the regulation of blood fluidity and fibrinolysis, vascular tone, angiogenesis, monocyte/leukocyte adhesion, and platelet aggregation.

The quantification of circulating endothelial cells (CEC) in blood samples is a rather novel and reliable method of assessing endothelial damage and endothelial dysfunction. It is assumend that CEC are mature cells that have detached from the inner most cell layer of blood vessels in response to endothelial injury.

Increased numbers of CECs in cardiovascular disease and its risk factors, such as unstable angina, acute myocardial infarction, stroke, diabetes mellitus, and critical limb ischemia have been reported. The enumeration of CEC after acute myocardial infarction has been shown to be an accurate predictor of major adverse coronary events and death.

  • Detecting Rare Cells in blood and other body fluids can be a real challenge. OncoLab provides research tools that make hunting for rare cells, circulating endothelial cells (CEC), a simple diagnostic test.
    OncoLab’s CEC test is based on fluorescent immunostaining of endothelial cells after enrichment from blood samples. State-of-the-art biomarkers coupled with enhanced scanning optical systems powered by artificial intelligence enable convenient and efficient research of CEC.
    The list of products comprises special blood collection tubes, tools and reagents for cell purification, proprietary immunofluorescent cocktails for staining (IF), tools and general use reagents for preparing cytology slides, microscope imaging, and image analysis.

    Product Unit Size REF IFU Brochure Note
    nPACTM CSC/CEC IF Kit 12 rxn OL5070012   not for in vitro diagnostic use
    Blood Collection Kit CE-IVD 12 samples OL6010112    
    CRC IF Materials Kit 12 samples OL5090012     not for in vitro diagnostic use
    nCyte DxTM Advanced Optical Scanner
    incl. nAble® Software
    1 instrument OL90100   not for in vitro diagnostic use