Cytokeratin 19 (CK-19) is a general marker of epithelial cells that is strongly expressed in epithelial but not in mesenchymal cells. Increased expression is seen during epithelial embryogenesis, tissue regeneration, tissue repair, tissue development, and carcinogenesis. CK-19 has been extensively studied as a potential marker for the detection of circulating tumor cells (CTC) in a variety of epithelial cancers. It is a cytoskeletal component present in normal and cancerous epithelial cells. It is expressed in 90% of invasive breast cancer tissue and thus, has been extensively used for the detection of breast cancer cells in mesenchymal tissues. It is probably the most sensitive and reliable tumor marker for the detection of CTC in patients with breast cancer.
The list of innovative products comprises RT-qPCR-based tests for the quantification of CK-19 mRNA in RNA samples.
|CK-19 Kit||24 tests||OL1011024||not for in vitro diagnostic use|
|CK-19 Kit LC||24 tests||OL1010024||not for in vitro diagnostic use|
|CK-19 Kit LC||48 tests||OL1010048||not for in vitro diagnostic use|
|CK-19 Kit LC||96 tests||OL1010096||not for in vitro diagnostic use|
|CK-19 Kit CE-IVD||24 tests||OL1010124||– coming soon|
|CC CK-19 610-670 Kit||1 run||OL0010006||not for in vitro diagnostic use|
|CC CK-19 610-670 Kit CE-IVD||1 run||OL0010106||– coming soon|
Detecting Rare Cells in blood and other body fluids can be a real challenge. OncoLab provides research tools that make hunting for rare cells, such as circulating tumor cells (CTC), circulating endothelial cells (CEC), or circulating stromal cells (CSC) a simple diagnostic test.
OncoLab’s Circulating Rare Cell (CRC) tests are based on fluorescent immunostaining of rare cells after enrichment from blood samples. State-of-the-art biomarkers coupled with enhanced scanning optical systems powered by artificial intelligence enable convenient and efficient research of CRC.
The list of products comprises special blood collection tubes, tools and reagents for cell purification, proprietary immunofluorescent cocktails for staining (IF), tools and general use reagents for preparing cytology slides, microscope imaging, and image analysis.
|nPACTM CTC IF Kit||12 rxn||OL5010012||not for in vitro diagnostic use|
|nPACTM CSC IF Kit||12 rxn||OL5080012||not for in vitro diagnostic use|
|nPACTM CSC/CEC IF Kit||12 rxn||OL5070012||not for in vitro diagnostic use|
|Blood Collection Kit CE-IVD||12 samples||OL6010112|
|CRC IF Materials Kit||12 samples||OL5090012||not for in vitro diagnostic use|
|nCyte DxTM Advanced Optical Scanner
incl. nAble® Software
|1 instrument||OL90100||not for in vitro diagnostic use|
Several tests for PCR-based detection and molecular characterization of circulating tumor cells (CTC) are under development.
The list of future products comprises multi-marker tests for breast cancer, lung cancer, ovarian cancer, cervical cancer, endometrial cancer, and neuroendocrine tumors. Tools and reagents for collecting and stabilizing patients‘ blood samples, enrichment of circulating rare cells (CRC), or depletion of unwanted cells are in the pipeline as well.
Methods and tests for the detection and quantification of protein aggregates are another focus of research and product development at OncoLab. Inactivation of protein function by aggregation plays an important role in cancer and several other diseases, like neurodegenerative disorders, amyloid transthyretin cardiomyopathy and type-2 diabetes. Products for the detection and quantification of disease associated aggregated proteins in tissues, cells and microvesicles are under development.
The diagnostic impact of cell-free circulating RNA (cfRNA) levels in various bodily fluids and preparation of exosomes is another research topic.
Proprietary mRNAs and miRNAs are investigated as possible diagnostic targets for gynecologic malignancies and other cancerous diseases.