EARLY DETECTION IS THE KEY TO AVOID AND CURE OVARIAN CANCER

THE LOC TEST: LAVAGE FOR OVARIAN CANCER

 

Ovarian cancer is the seventh most common cancer in women worldwide and is the most serious gynaecological cancer. Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these women will die from their disease. Ovarian cancer has the lowest survival rate of all gynecologic cancers, and is characterized around the world by a lack of awareness of symptoms and late stage diagnosis. When detected early, surgical cure rates exceed 90%, but currently most cases are detected at an advanced stage when the cancer has already disseminated.

Our most pressing problem in ovarian cancer is a lack of tools to identify early stage disease when resection plus chemotherapy can achieve a complete cure. If the desease is detected in a pre-malignant state, the outbreak of cancer can be avoided at all.

INNOVATIVE

Our LOC Test is the first proven diagnostic test for the earlier cancer detection. The LOC Test test will lead to earlier diagnosis of ovarian cancer and endometrial cancer by physicians and, therefore, earlier surgical interventions which have been proven to extend patient survival rates, and often provide cure in early stage disease. The LOC Test is being developed so that it is able to detect the desease in a pre-cancerous stage as well. 

EASY

Our LOC Test can be easily applied by any gynaecologist, who underwent a short training, which makes it perfectly suitable for an envisaged future population-wide screening, similar to the PAP smear test.

RELIABLE

With our LOC Test test we empower physicians to offer their patients a comprehensive, reliable and affordable diagnostic test and providing them with more information regarding crucial decisions with respect to their health. This fact is especially important for patients who have a familiar background of ovarian cancer or breast cancer, as they have a high risk to develop ovarian cancer too.

RATIONAL

The most prominent type of ovarian cancer (high-grade serous ovarian cancer, HGSOC) is considered to originate at the surface of the fimbriated end of the fallopian tubes. These pre-malignant lesions, called serous tubal intraepithelial carcinoma (STIC), shed cells that can be detected in the uterine cavity. Also, shed ovarian carcinoma cells migrate through the fallopian tubes into the uterine cavity. These pre-malignant or malignant cells can be collected by a lavage of the uterine cavity and analysed using molecular methods (e.g., gene mutations detected by next generation sequencing).

HOW DOES THE LAVAGE TEST WORK?

Collection of Cells

The LOC Test can be done by any gynaecologist or general practitioner who underwent a short special training. The lavage is performed under local anesthesia. Patients have described the procedure to be less painful than inserting an intrauterine device (IUD).

During the lavage sterile saline is slowly flushed into the uterine cavity and fallopian tubes with a 10 mL syringe through one line of our proprietary three-way Speiser Catheter. Simultaneously the fluid is aspirated with a second 10 mL syringe through the other line. While one syringe slowly empties, the other slowly fills up. The catheter is fixed in the uterine cavity by a small inflatable balloon. The so collected lavage sample is mixed with a stabiliser fluid and shipped to our service laboratory.

 Analysis of Samples

Cells are collected from the lavage fluids by centrifugation and analysed for the presence of somatic mutations in the gene TP53 and other selected genes by ultra-deep, targeted sequencing.

OUR PROPRIETARY CATHETER

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Our innovative three-way catheter – the Speiser Catheter –  was designed and developed specifically for this application by our medical advisor Prof. Paul Speiser. MEDICOPLAST MF 13006, catheter for uterine and tubal lavage.

To order the Speiser Catether send us an e-mail:

THE ADVANTAGES OF THE LOC TEST AT A GLANCE:

- very easy handling

- training documentation included

- application in clinical and outpatient setting under local anesthesia

- perfectly applicable in clinical routine

- almost painless for patients

- short procedure (approx. 5-10 min)

Send us an e-mail for more information or ordering the Speiser Catheter:
office@oncolab.at

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OncoLab Diagnostics GmbH
Mahlerstrasse 13
1010 Vienna
Austria

© OncoLab Diagnostics GmbH, 2017